24. David Botstein David Botstein开创核酸限制性片段
长度多态性分析技术,用于标志不同
个体间的基因差别,为后来的人类基
因组计划奠定了基础。
PRINCETON, N.J. -- Princeton University has
named David Botstein, a renowned geneticist,
educator and pioneer of the Human Genome Project, as the
new director of the Lewis-Sigler Institute for Integrative
Genomics.
25. 第1篇有关人类RFLP实验论文 A Highly Polymorphic Locus in Human DNA
Arlene R. Wyman and Ray White, MIT
A locus in the human genome, not associated with any specific gene,
has been found to be a site of restriction fragment length
polymorphism. The polymorphism was found by hybridizing a 16-
kilobase-pair segment of single-copy human DNA, selected from
the human genome library cloned in phage CH4A, to a Southern
transfer of total human DNA digested with EcoRI. DNAs from a
number of individuals from within Mormon pedigrees as well as
random individuals have been examined. The locus is highly
variable, with at least eight alleles present, homozygotes accounting
for less than 25% of the individuals examined.
---PNAS | November 1, 1980 | vol. 77 | no. 11 | 6754-6758